{"id":769,"date":"2012-04-19T10:54:12","date_gmt":"2012-04-19T14:54:12","guid":{"rendered":"http:\/\/xal.li\/eri\/?p=769"},"modified":"2012-04-19T10:54:13","modified_gmt":"2012-04-19T14:54:13","slug":"bucky-spice","status":"publish","type":"post","link":"http:\/\/xal.li\/eri\/everything\/bucky-spice\/","title":{"rendered":"Bucky Spice"},"content":{"rendered":"<p>From <a href=\"http:\/\/l.xal.li\/HVTBjR\"><strong>The prolongation of the lifespan of rats by repeated oral administration of [60] fullerene<\/strong><\/a>:<\/p>\n<blockquote><p><i>&#8230;<\/p>\n<p>3.3. Chronic toxicity and effects of C<sub>60<\/sub> on lifespan of rats<\/i><\/p>\n<p>Fig. 3 shows the animal survival and growth. After \u00ef\u00ac\u0081ve months of treatment (M<sub>15<\/sub>) one rat treated with water only exhibited some palpable tumours in the abdomen region. Due to the rapid development of tumours (about 4 cm of diameter) this rat died at M<sub>17<\/sub>. As rats are known to be sensitive to gavages, we decided to stop the treatment for all rats and to observe their behaviour and overall survival.<\/p>\n<p>All remaining animals survived with no apparent sign of behavioural trouble until M<sub>25 <\/sub>(Fig. 3a). At the end of M<sub>25<\/sub> the animals of the control groups showed signs of ulcerative dermatitis with ageing while C<sub>60<\/sub>-treated animals remained normal. As the growths of all surviving animals showed no signi\u00ef\u00ac\u0081cant difference until M<sub>30<\/sub> (Fig. 3b) indicating that the treatment did not alter their food intake, we continued observing their survival.<\/p>\n<p>At M<sub>38<\/sub> all water-treated control rats were dead (Fig. 3a). This agrees with the expected lifespan of this animal species that is thirty to thirty six months. At this time 67% of olive-oil-treated rats and 100% of C<sub>60<\/sub>-treated rats were still alive.<\/p>\n<p>The survival distributions for C<sub>60<\/sub>-olive oil-treated rats and controls were estimated by the non-parametric Kaplane\u00e2\u20ac\u201cMeier estimator (Fig. 3) and compared by a log-rank estimated test. The estimated median lifespan (EML) for the C<sub>60<\/sub>-treated rats was 42 months while the EMLs for control rats and olive oil-treated rats were 22 and 26 months, respectively. These are increases of 18 and 90% for the olive-oil and C<sub>60<\/sub>-treated rats, respectively, as compared to controls.<\/p>\n<p>The log-rank test leads to \u00ce\u00a7<sup>2<\/sup> values (one degree of freedom) of 7.009, 11.302, and 10.454, when we compare water-treated and olive oil-treated rats, water-treated and C<sub>60<\/sub>-treated rats, and olive oil-treated and C<sub>60<\/sub>-treated rats, respectively. This means that olive oil extends the lifespan of rats with respect to water with a probability of 0.99 while C<sub>60<\/sub>-olive oil extends the lifespan of C<sub>60<\/sub>-treated rats with a probability of 0.999 and 0.995 with respect to water and olive oil treatments, respectively.<\/p>\n<p><em>&#8230;<\/em>\n<\/p><\/blockquote>\n<p>\nSo I guess doubling the expected lifespan of a lab rat after seven months of daily dosing counts as no measurable levels of toxicity to C<sub>60<\/sub> buckyballs. Hunh.<\/p>\n<p>[*]<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>____________<br \/>\nBaati T, et al., <a href=\"http:\/\/l.xal.li\/HVTBjR\"><strong>The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene<\/strong><\/a>, Biomaterials (2012), doi:10.1016\/j.biomaterials.2012.03.036<\/p>\n","protected":false},"excerpt":{"rendered":"<p>From The prolongation of the lifespan of rats by repeated oral administration of [60] fullerene: &#8230; 3.3. Chronic toxicity and effects of C60 on lifespan of rats Fig. 3 shows the animal survival and growth. After \u00ef\u00ac\u0081ve months of treatment (M15) one rat treated with water only exhibited some palpable tumours in the abdomen region. [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"footnotes":"","_jetpack_memberships_contains_paid_content":false,"jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":false,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false},"version":2}},"categories":[1],"tags":[],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_shortlink":"https:\/\/wp.me\/p1rL5j-cp","jetpack_sharing_enabled":true,"_links":{"self":[{"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/posts\/769"}],"collection":[{"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/comments?post=769"}],"version-history":[{"count":1,"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/posts\/769\/revisions"}],"predecessor-version":[{"id":770,"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/posts\/769\/revisions\/770"}],"wp:attachment":[{"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/media?parent=769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/categories?post=769"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/xal.li\/eri\/wp-json\/wp\/v2\/tags?post=769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}